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    1. Computational and Systems Biology
    2. Evolutionary Biology

    A community-maintained standard library of population genetic models

    Jeffrey R Adrion et al.
    The stdpopsim library, a community-driven open source project, is presented which provides easy access to a standard catalog of published simulation models for population genetics aimed at field-wide standardization.
    1. Neuroscience

    CaImAn an open source tool for scalable calcium imaging data analysis

    Andrea Giovannucci et al.
    CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Claudin-2-dependent paracellular channels are dynamically gated

    Christopher R Weber et al.
    Paracellular, trans-tight junction channels, which communicate between two extracellular compartments without crossing the plasma membrane, are a new class of ion channel with unitary behaviors similar to traditional transmembrane channels.
    1. Ecology

    Mammal communities are larger and more diverse in moderately developed areas

    Arielle Waldstein Parsons et al.
    Citizen science camera trapping showing suburban and wild areas maintain similar levels of mammalian diversity and relative abundance, challenging conventional thoughts about the impacts of urbanization on wildlife.
    1. Computational and Systems Biology
    2. Medicine

    NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

    Homa MohammadiPeyhani et al.
    NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.
    1. Neuroscience

    Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

    Loes Koelewijn et al.
    Electrophysiology pinpoints brain function abnormalities in young people genetically at risk of developing Alzheimer's disease much later in life, supporting theories of initial hyperconnectivity driving eventual profound disconnection.
  1. Scientific Publishing: Launching eLife, Part 1

    Randy Schekman et al.
    The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results.
    Editorial
    Available as:
    • HTML
    • PDF
  2. Scientific Publishing: Launching eLife, Part 2

    Randy Schekman et al.
    With a commitment to open access and innovation in peer review, eLife aims to publish important results in the life and biomedical sciences in a flexible digital format that allows authors to present their work in full, including the key data on which the conclusions are based.
    Editorial
    Available as:
    • HTML
    • PDF
  3. Scientific Publishing: A year in the life of eLife

    Randy Schekman et al.
    Improving the peer review process, overcoming the limitations of print journals and providing open access to the very best work in the life and biomedical sciences are three highlights of our first year.
    Editorial
    Available as:
    • HTML
    • PDF
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar et al.
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.