3,244 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An open-source computational and data resource to analyze digital maps of immunopeptidomes

    Etienne Caron et al.
    A community-based international effort generates standardized HLA allele-specific peptide assay libraries and enables the analysis of the human immunopeptidome by SWATH mass spectrometry.
    1. Biochemistry and Chemical Biology

    Point of View: How open science helps researchers succeed

    Erin C McKiernan et al.
    Open research practices bring significant benefits to researchers.
    1. Neuroscience

    Building a functional connectome of the Drosophila central complex

    Romain Franconville et al.
    The central complex, a highly conserved insect brain region important for navigation, is characterized by a high degree of recurrence and a sparseness of output pathways.
  1. Scientific Publishing: Launching eLife, Part 2

    Randy Schekman et al.
    With a commitment to open access and innovation in peer review, eLife aims to publish important results in the life and biomedical sciences in a flexible digital format that allows authors to present their work in full, including the key data on which the conclusions are based.
    Editorial
    Available as:
    • HTML
    • PDF
    1. Neuroscience

    Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

    Pengcheng Zhou et al.
    A new open-source computational toolbox for processing in vivo microendoscopic calcium imaging data performs signal demixing and denoising much more accurately than previously available methods, significantly improving the utility of this imaging modality.
    1. Genetics and Genomics

    Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

    Matthias Thurner et al.
    Human pancreatic islet high-resolution chromatin state maps generated from DNA methylation, open chromatin and ChIP-seq mark data facilitate the characterisation of regulatory mechanisms at type 2 diabetes genome-wide association study loci.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Cell-accurate optical mapping across the entire developing heart

    Michael Weber et al.
    The combination of high-speed light sheet microscopy and suitable data analysis facilitates cell-accurate measurements across entire organs and opens the way to systematic, scale-bridging, in vivo studies of organogenesis.
  2. Open notebooks galore: The Structural Genomics Consortium

    Over 20 researchers will show their support for open science by sharing their data and blogging about their research projects.
  3. Goodtables.io logo

    Data reusability: a pilot with goodtables

    We worked with Open Knowledge International to investigate the reusability of data shared with eLife.
  4. Human outline surrounded by silhouettes of different animals used in research

    Connecting biomedical knowledge through the Monarch Initiative

    The Monarch Initiative integrates open life sciences and biomedical data to improve disease discovery and diagnostics.

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