A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
Glenn A Maston, Lihua Julie Zhu ... Michael R Green
The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.
A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
Alexandre Martinière, Aurélie Bak ... Martin Drucker
Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.
The enzyme that collaborates with ubiquitin ligases to promote the release of defective polypeptides from stalled ribosomes in a process named ribosome-associated degradations has been identified as the ATPase Cdc48.
Ursula Schulze-Gahmen, Heather Upton ... Tom Alber
Structure-function analysis of the super elongation complex formed when HIV replicates inside cells reveals that the HIV-1 Tat protein binds to a cleft between P-TEFb, an enzyme that is involved in normal transcription, and AFF4, a protein that is used to build the super elongation complex
A protein complex that enables cells to transport substances across their membranes, and that typically consists of four subunits, can also function as two hemicomplexes, each with two subunits.
By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
John H Koschwanez, Kevin R Foster, Andrew W Murray
The ability to share resources for the benefit of all members of a group may have driven ancient organisms to evolve from a unicellular to a multicellular state.