Guangliang Wang, Surendra K Rajpurohit ... Jeff S Mumm
A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
Low-frequency correlations among neurons in monkey visual area V4 impair the animal's ability to perform an attention-demanding task, suggesting a causal role of these fluctuations in perception.
Aleksandra Z Płochocka, Miguel Ramirez Moreno ... Lyubov Chumakova
Computational, theoretical, and in vivo studies reveal that in epithelia the self-organization of apical microtubules is robustly determined by cell geometry and minus-end distribution, not organism environment or genetics.
The transcription factor Xrp1 mediates a previously unrecognized branch of stress-response signaling, specifically as a downstream effector of eIF2alpha kinases.
Melanocortin 1 receptor (MC1-R) deficiency in hepatocytes increases cholesterol levels in the circulation and liver in mice, while selective activation of MC1-R reduces cellular cholesterol content in cultured hepatocytes.
Friederike E Kohrs, Ilsa-Maria Daumann ... P Robin Hiesinger
The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.
Structural rearrangements of meiotic spindles during the transition from metaphase to anaphase can be controlled by local changes of microtubule dynamics, such as nucleation and/or turnover, and that katanin promotes microtubule turnover by severing microtubules near the chromosomes.
Jasmin van den Heuvel, Caroline Ashiono ... Ulrike Kutay
Endoproteolytic cleavage of the ribosomal precursor protein FUBI-eS30 is required for efficient maturation of small ribosomal subunits in the cytoplasm of human cells and involves the nucleolar deubiquitinase USP36.
Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
