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    1. Neuroscience

    The breath shape controls intonation of mouse vocalizations

    Alastair MacDonald, Alina Hebling ... Kevin Yackle
    The breathing motor program is re-engaged to control the fluctuations in vocal pitch during a sound.
    1. Structural Biology and Molecular Biophysics

    Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

    Demeng Sun, Sanling Liu ... Lei Liu
    Mambalgin1 binds to the thumb domain of human ASIC1a channel and inhibits the channel through hindering the proton-induced transitions from the resting closed state to the active and/or desensitized state.
    1. Neuroscience

    Molecular and anatomical characterization of parabrachial neurons and their axonal projections

    Jordan L Pauli, Jane Y Chen ... Richard D Palmiter
    A guide summarizing the diversity of cell types in the parabrachial nucleus.
    1. Neuroscience

    Constructing an adult orofacial premotor atlas in Allen mouse CCF

    Jun Takatoh, Jae Hong Park ... Fan Wang
    A new three-step monosynaptic premotor tracing strategy in adult mice, together with registration to the Allen mouse common coordinate framework, uncovered precise spatial relationships of distinct orofacial premotor circuits in the brainstem.
    1. Neuroscience

    Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

    William Menegas, Joseph F Bergan ... Mitsuko Watabe-Uchida
    Dopamine neurons projecting to different targets receive a similar set of inputs, rather than forming reciprocal connections, whereas those projecting to the posterior striatum receive a distinct set of inputs.
    1. Genetics and Genomics

    Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

    Hyeonsoo Jeong, Nicole M Baran ... Soojin V Yi
    Comprehensive genomic and population genetic analyses of a non-recombining chromosome in white-throated sparrows reveal the actions of purifying selection, positive selection, and balancing selection, expanding our understanding of supergene evolution.
    1. Neuroscience

    Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses

    Bernard Bloem, Rafiq Huda ... Ann M Graybiel
    Simultaneous 2-photon imaging of striosomes and matrix in mice shows that striosomes preferentially encode reward-predicting cues whereas both striatal compartments demonstrate reward-related activity.
    1. Neuroscience

    Sex-dependent, lateralized engagement of anterior insular cortex inputs to the dorsolateral striatum in binge alcohol drinking

    David L Haggerty, Brady K Atwood
    Engagement of anterior insular cortex projections to the dorsolateral striatum underpins sex-differences in binge alcohol consumption behaviors.
    1. Neuroscience

    Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments

    Subhojit Chakraborty, Nils Kolling ... Anna S Mitchell
    In monkeys, the integrity of the magnocellular subdivision of mediodorsal thalamus is important when using recent rewarded choices to promote persistence with a recently sampled choice during changing or uncertain reward guided-learning and decision-making tasks.
    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal, Wei-Hsiang Huang ... Paul A Gray
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.