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    1. Neuroscience

    Opioids modulate an emergent rhythmogenic process to depress breathing

    Xiaolu Sun et al.
    Inspiratory rhythmogenesis is mediated by an emergent mechanism independent of bursts associated with motor output and is modulated by opioids, pointing to strategies for ameliorating opioid-induced respiratory depression.
    1. Neuroscience

    In vivo detection of optically-evoked opioid peptide release

    Ream Al-Hasani et al.
    In vivo detection of optically evoked endogenous opioid peptides reveals anatomically distinct release profiles.
    1. Neuroscience

    Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

    Seksiri Arttamangkul et al.
    Opioid sensitive neurons were identified using a traceless affinity labeling strategy to covalently label endogenous mu-opioid receptors with fluorescent compounds in living brain slices from wild type animals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

    Kathryn E Livingston et al.
    Opioid drug efficacy and allosteric modulation is measured using an active state sensor of the mu-opioid receptor.
    1. Neuroscience

    Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice

    Lara S Hwa et al.
    Heavy alcohol drinking primes dynorphin /kappa opioid systems in the bed nucleus of the stria terminalis to alter stress responses in mice.
    1. Neuroscience

    Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

    Shanna L Resendez et al.
    The neural mechanisms that underlie the maintenance of social bonds between prairie voles suggest that social support networks may be a powerful way of treating addiction.
    1. Neuroscience

    Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

    Seksiri Arttamangkul et al.
    The role of C-terminal phosphorylation is critical for the expression of acute desensitization, trafficking and long-term tolerance to morphine.
    1. Neuroscience

    Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

    Sebastian Korb et al.
    Administration of dopamine and opioid receptor antagonists resulted in reduced reward anticipation (effort and increased negative facial reactions), but only administration of opioid antagonists resulted in reduced liking (facial reactions).
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions

    Kohki Kido et al.
    AirID provides highly interaction-dependent biotinylation for analysis of protein–protein interaction.
    1. Neuroscience

    Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats

    Dvir Blivis et al.
    A novel mechanism for gating nociceptive sensory-motor behavior is identified in freely behaving rats using high-speed videography that is controlled by posture and modulated by opioid and non-opioid receptor-dependent processes.