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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions

    Kohki Kido et al.
    AirID provides highly interaction-dependent biotinylation for analysis of protein–protein interaction.
    1. Neuroscience

    Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats

    Dvir Blivis et al.
    A novel mechanism for gating nociceptive sensory-motor behavior is identified in freely behaving rats using high-speed videography that is controlled by posture and modulated by opioid and non-opioid receptor-dependent processes.
    1. Plant Biology

    Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID

    Melina Zourelidou et al.
    Two protein kinases are required to activate auxin efflux transporters from plants.
    1. Cell Biology
    2. Neuroscience

    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

    Thibaut Laboute et al.
    GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.
    1. Stem Cells and Regenerative Medicine

    AIRE is a critical spindle-associated protein in embryonic stem cells

    Bin Gu et al.
    AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.
    1. Neuroscience

    Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

    Gregory G Grecco et al.
    A novel, translational mouse model of prenatal methadone exposure was developed and a longitudinal assessment of offspring revealed impairments in physical, behavioral, and neuronal development.
    1. Neuroscience

    Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system

    Christian Buchel et al.
    The pleasure of rewards in humans is mediated by an opioidergic mechanism.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Computational design of environmental sensors for the potent opioid fentanyl

    Matthew J Bick et al.
    State-of-the-art computational methods have facilitated the construction of plant-based sentinels for detecting toxic molecules in the environment.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9

    Laurens M van Tienen et al.
    BCL9/Legless is an integral component of the Wnt enhanceosome, harboring binding sites in its conserved C-terminus for multiple core components of this complex including ChiLS and Groucho/TLE.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland et al.
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.