191 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen, Anders S Hansen ... Xavier Darzacq
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Most primary olfactory neurons have individually neutral effects on behavior

    Tayfun Tumkaya, Safwan Burhanudin ... Adam Claridge-Chang
    Of the 50 primary olfactory channels in vinegar flies, only 10 drive avoidance or approach behavior when activated by themselves, indicating that most olfactory responses are multi-channel responses that follow complex combination rules.
    1. Neuroscience

    Dopamine neuron dependent behaviors mediated by glutamate cotransmission

    Susana Mingote, Nao Chuhma ... Stephen Rayport
    The conditional reduction of glutaminase in mouse dopamine neurons selectively attenuates glutamate cotransmission at phasic frequencies, revealing the role of dopamine neuron glutamate cotransmission in the attribution of motivational salience.
    1. Neuroscience

    The neural dynamics of positive and negative expectations of pain

    Christoph Arne Wittkamp, Maren-Isabel Wolf, Michael Rose
    Pain expectation processing shifts from uniform anticipatory activation to valence-specific differentiation during sensory input.
    1. Stem Cells and Regenerative Medicine

    Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila

    Zhixin Ma, Wenshu Wang ... Su Wang
    Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.
    1. Cell Biology
    2. Physics of Living Systems

    Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

    Kaushikaram Subramanian, Martin Weigert ... Moritz Kreysing
    Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
    1. Developmental Biology

    m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

    Yanling Xin, Qinghai He ... Shuyi Chen
    m6A fine-tunes transcriptomic transition from neural progenitors to glial cells in the retina.
    1. Structural Biology and Molecular Biophysics

    Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans

    Jihee Hwang, Jae-Yeol Kim ... Nam Ki Lee
    RecO efficiently displaces SSB from ssDNA without consuming ATPs using its two DNA-binding sites, even though SSB binds to ssDNA approximately 300 times more strongly than RecO does.
    1. Cancer Biology

    The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

    Jaime N Wertman, Nicole Melong ... Jason N Berman
    L-mimosine and dopamine protect against cisplatin-induced oto- and nephrotoxicity in zebrafish and human cell line models.

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