316 results found
    1. Developmental Biology
    2. Physics of Living Systems

    The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism

    David J Jörg et al.
    A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
    1. Neuroscience

    Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain

    Kazunori Shinomiya et al.
    A complete connectome of the ON and OFF motion pathways of the Drosophila optic lobe is acquired using three-dimensional EM methods, and the similarities and differences of the two pathways are uncovered.
    1. Neuroscience

    The comprehensive connectome of a neural substrate for ‘ON’ motion detection in Drosophila

    Shin-ya Takemura et al.
    Connectomic analysis identifies the complex circuits of a visual motion-sensing neuron that qualify them to generate direction-selective motion sensing signals using both Hassenstein-Reichardt and Barlow-Levick models.
    1. Neuroscience

    Visual Behavior: The eyes have it

    Mehmet Keleş, Mark A Frye
    Molecular genetic experiments are revealing how the fly brain generates behavioral responses to visual stimuli.
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    1. Developmental Biology
    2. Neuroscience

    Developmental Neuroscience: Re-utilization of a transcription factor

    Filipe Pinto-Teixeira, Claude Desplan
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    1. Developmental Biology
    2. Neuroscience

    Neurotransmitter Identity: A question of lineage

    Sonia Sen
    In the ventral nerve cord of fruit flies, neurons from the same hemilineage use the same neurotransmitter.
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    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Developmental Biology
    2. Genetics and Genomics

    Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim

    Elizabeth M Knapp et al.
    Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

    Danyang Zhang et al.
    GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.
    1. Developmental Biology

    A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis

    Kuan Zhang et al.
    Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a Wnt5a–Ror2–Vangl2 axis is a major determinant of alveolar formation.

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