464 results found
    1. Neuroscience

    mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

    Linqing Miao et al.
    The kinase AKT acts as a nodal point that coordinates both positive and negative cues to regulate the regeneration of central nervous system axons in adult mice.
    1. Cell Biology
    2. Neuroscience

    Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

    Craig S Pearson et al.
    4-sulfation at the non-reducing end of chondroitin sulfate glycosaminoglycan chains is essential for inhibition of axonal growth.
    1. Cell Biology
    2. Neuroscience

    Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

    Martin Larhammar et al.
    Two seemingly distinct cellular stress response pathways that contribute to neurodegeneration after axonal insults are now revealed to be under the control of a single master regulator of the neuronal injury response, the kinase DLK.
    1. Neuroscience

    PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

    Yevgeniya A Mironova et al.
    The signaling lipid PI(3,5)P2 supports the formation of the myelin sheath, by regulating trafficking of myelin building blocks within oligodendrocytes and communication between oligodendrocytes and neuronal axons.
    1. Neuroscience

    Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

    Jie Zhang et al.
    An effective and reversible mouse glaucoma model that replicates the secondary glaucoma in human patients caused by silicone oil after retina surgeries presents significant neurodegeneration, and is suitable for neuroprotectants selection.
    1. Neuroscience

    Monitoring ATP dynamics in electrically active white matter tracts

    Andrea Trevisiol et al.
    ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.
    1. Neuroscience

    Axons: The cost of communication in the brain

    Brian A MacVicar et al.
    Imaging ATP in axons reveals that they rely on glucose from the blood and lactate produced by glial cells as sources of energy.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Circadian Rhythms: Feeding time

    Hugh D Piggins , David A Bechtold
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  1. Point of View: Unbridle biomedical research from the laboratory cage

    Garet P Lahvis
    Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
  2. Living Science: Teaching for the future

    Indira M Raman
    Reading and discussing classic papers can be an effective way of teaching graduate students how to learn the skills they will need for a career in research.

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