2,840 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

    Yamila N Torres Cleuren et al.
    Quantitative genetic analyses reveal remarkably broad genetic variation underlies the requirement for two critical regulatory inputs into a core embryonic gene regulatory network within one animal species.
    1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen et al.
    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
    1. Developmental Biology
    2. Evolutionary Biology

    Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

    Sruthi Purushothaman et al.
    While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.
    1. Evolutionary Biology

    Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

    Wen Xu et al.
    Gene sharing through different isoforms can precede the formation of independent genes.
    1. Neuroscience

    RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

    Marisa M Brockmann et al.
    The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.
    1. Evolutionary Biology

    Molecular function limits divergent protein evolution on planetary timescales

    Mariam M Konaté et al.
    Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
    1. Neuroscience

    Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum

    Masashi Kameda et al.
    Neurons in the striatum exhibited periodic firing in monkeys attempting to detect omission of repetitive visual stimulus, while the phase of neuronal activity differed from that observed in the cerebellum.
    1. Cell Biology
    2. Plant Biology

    Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

    Charlotte Kirchhelle et al.
    In lateral roots, cells employ a novel pathway to cell edges to control directional growth, which acts independently of the leading paradigm of oriented deposition of cellulose microfibrils at faces.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba et al.
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is enhanced by tailoring instruction to individual genetic differences

    David G Mets, Michael S Brainard
    Tailoring instructive experience to individual genetic biases improves vocal learning outcomes across genetic backgrounds in the Bengalese finch.

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