Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.

Automated whole-brain analysis of gene expression at cellular resolution detects previously overlooked phenotypes in mutants and reveals parallels between the forebrains of zebrafish and mammals.

New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.

A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.

Virtual investigation of the 3.67-million-year-old skull of 'Little Foot' using synchrotron radiation reveals histological details of Australopithecus dental and bone tissues.

Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.

Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.

Wnt11 maintains nephron progenitor niche integrity during kidney development through its modulation of cellular dynamics.

High-resolution template matching makes small, densely embedded proteins detectable.

Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.