1,594 results found
    1. Neuroscience

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala

    Linnaea E Ostroff et al.
    A diverse assortment of mRNAs are present in projection axons in the adult forebrain and their translation is associated with new memory formation.
    1. Structural Biology and Molecular Biophysics

    Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer

    Van K Duesterberg et al.
    The combined use of optical trapping and single-molecule FRET permits the study of riboswitch structure formation and conformational dynamics at the same time.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

    Michael S Woody et al.
    Cardiac myosin converts energy from ATP into mechanical work by transitioning from a short-lived force-bearing state, to a post working stroke state before the release of inorganic phosphate.
    1. Developmental Biology
    2. Evolutionary Biology

    An ancestral apical brain region contributes to the central complex under the control of foxQ2 in the beetle Tribolium

    Bicheng He et al.
    An ancestral apical brain center contributed to the evolution of the insect central complex requiring foxQ2, which is essential for the development of midline structures of the insect brain.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

    Breane G Budaitis et al.
    Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
    1. Structural Biology and Molecular Biophysics

    Structural basis of αE-catenin–F-actin catch bond behavior

    Xiao-Ping Xu et al.
    A molecular mechanism for force-dependent binding of the cell adhesion proteins αE-catenin and vinculin to actin is derived from the structure of the αE-catenin actin-binding domain bound to F-actin.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips

    Jonathan W Driver et al.
    The protofilaments that curl outward from a disassembling microtubule tip carry a large amount of strain energy and they can drive movement with an efficiency similar to conventional motor proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Reconstitution reveals two paths of force transmission through the kinetochore

    Grace E Hamilton et al.
    Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.
    1. Cell Biology
    2. Developmental Biology

    A nanobody-based toolset to investigate the role of protein localization and dispersal in Drosophila

    Stefan Harmansa et al.
    Functionalized protein binders, anchored to specific regions along the cell cortex, provide a novel approach to directly modify protein localization and dispersal in vivo.

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