1,125 results found
    1. Human Biology and Medicine

    Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1

    Emilie Auxerre-Plantié et al.
    Drosophila DM1 models suggest that elevated cardiac expression of straightjacket/α2δ3, a regulatory subunit of voltage-gated calcium channel, contributes to cardiac conduction defects in DM1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

    Tomoki Naito et al.
    GRAMD1 proteins sense a transient expansion of the accessible pool of plasma membrane cholesterol and facilitate its transport to the endoplasmic reticulum at ER-PM contact sites.
    1. Structural Biology and Molecular Biophysics

    Multiple kinesins induce tension for smooth cargo transport

    Marco Tjioe et al.
    After developing a force-gliding assay with nanometer and piconewton precision, it is concluded that multiple kinesins driving a single cargo induces tension, resulting in smooth cargo transport, even with roadblocks.
    1. Cell Biology

    Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

    Mario Ruiz et al.
    Silencing the acyl-coA synthethase ACSL1 protects against saturated fat lipotoxicity by preventing the degradation of polyunsaturated fatty acids, allowing them to be incorporated into phospholipids and improves membrane fluidity.
    1. Neuroscience

    Single cell transcriptome atlas of the Drosophila larval brain

    Clarisse Brunet Avalos et al.
    Single-cell transcriptomics identifies cellular composition of the first instar Drosophila brain and the response to starvation.
    1. Ecology

    Biophysical and physiological processes causing oxygen loss from coral reefs

    Cynthia B Silveira et al.
    Coral reef heterotrophic bacteria and fleshy macroalgae cause oxygen loss from reef systems through microbial biomass accumulation and ebullition from algae surfaces.
    1. Neuroscience
    2. Physics of Living Systems

    Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

    Andrew R McKinstry-Wu et al.
    Responses to anesthetics differ among individuals and fluctuate stochastically despite constant drug concentration, however, the amount of noise driving transitions between the responsive and the unresponsive state is conserved.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus

    Paola Bardetti et al.
    Degradation of a mitotic inducer coordinates the transition of two successive cell cycle arrests during the infective process of a plant pathogenic fungus.
    1. Cell Biology
    2. Neuroscience

    Neurotrophins induce fission of mitochondria along embryonic sensory axons

    Lorena Armijo-Weingart et al.
    Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.

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