1,149 results found
    1. Biochemistry and Chemical Biology

    The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

    Purnima Klingauf-Nerurkar et al.
    The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.
    1. Neuroscience

    Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice

    Samantha Washburn et al.
    Acute knock down of Sgce that is mutated in Myoclonus Dystonia (DYT11), in the cerebellum of mice, leads to dystonia and myoclonus-like motor signs that like patients improve with alcohol.
    1. Neuroscience

    mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

    Nadege Morisot et al.
    In the orbitofrontal cortex, mTORC1, a multiprotein complex centered around the kinase mTOR, contributes to the development and/or maintenance of habitual alcohol seeking.
    1. Cancer Biology

    MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

    Renumathy Dhanasekaran et al.
    MYC and Twist1 drive metastasis by a novel non-cell-autonomous transcriptional mechanism of eliciting a cytokinome that mediates the crosstalk between cancer cells and macrophages, and its therapeutic blockade inhibits metastasis.
    1. Structural Biology and Molecular Biophysics

    Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

    Celso M Teixeira-Duarte et al.
    Cations are essential cofactors in the ATP activation mechanism of the KtrAB cation channel and appear to be cofactors of many other nucleotide-dependent RCK domains.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira et al.
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Cell Biology
    2. Immunology and Inflammation

    A role for phagocytosis in inducing cell death during thymocyte negative selection

    Nadia S Kurd et al.
    Self-reactive thymocyte death is most efficient when peptide-presenting cells are phagocytic, and blocking phagocytosis inhibits self-reactive thymocyte death, suggesting that phagocytes play central roles during thymocyte negative selection.
    1. Chromosomes and Gene Expression

    The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast

    Io Nam Wong et al.
    Genomic deletions formed from inter-fork strand annealing associated with a collapsed replication fork are suppressed by the FANCM-related DNA helicase Fml1 in conjunction with its partner proteins Mhf1 and Mhf2.
    1. Neuroscience

    Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

    Yoshinori Aso et al.
    The interplay of nitric oxide and dopamine specialize one memory unit in a fly brain in predicting the value of odors based only on recent experience.
    1. Structural Biology and Molecular Biophysics

    HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

    Michael Morse et al.
    APOBEC3G, an anti-viral protein with the capability to inhibit HiV-1 infectivity, binds single stranded DNA in multiple physical conformations, enabling complex interactions that allow APOBEC3G to perform multiple diverse functions.

Refine your results by:

Type
Research categories