466 results found
    1. Neuroscience

    Cortical signatures of precision grip force control in children, adolescents, and adults

    Mikkel Malling Beck et al.
    Precise motor control is supported by connectivity within a cortical grasping network from childhood to adulthood, but older individuals display more top-down control and superior motor performance compared to children.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

    Rossana Droghetti et al.
    Mathematical modeling and data analysis show that, over evolutionary times, the yeast temporal program of replication strives to avoid stalling events and minimize interference between neighbor origins.
    1. Cancer Biology

    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

    Alba Nicolas-Boluda et al.
    Tumor stiffness blocks T cell migration in tumors.
    1. Neuroscience

    Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

    Pablo J Lituma et al.
    By facilitating glutamate and BDNF release, presynaptic NMDA receptors may control information transfer from the dentate gyrus to the CA3 area of the hippocampus.
    1. Neuroscience

    Introduction to the EQIPD quality system

    Anton Bespalov et al.
    A system has been developed that supports generation of reliable basic biomedical research data while being open-access and lean with no negative impact on freedom of scientific exploration.
    1. Neuroscience

    Punishment insensitivity in humans is due to failures in instrumental contingency learning

    Philip Jean-Richard-dit-Bressel et al.
    Punishment insensitive individuals are not more impulsive or anxious, they dislike aversive outcomes and predictors of these outcomes, but are simply less likely to learn their control over them.
    1. Cell Biology
    2. Immunology and Inflammation

    Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

    Nadja Kern et al.
    Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.
    1. Biochemistry and Chemical Biology

    Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

    Hongki Song et al.
    Sec18(NSF) and Sec17(αSNAP) provide a parallel pathway to fusion that is independent of energy from SNARE zippering.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

    Andrew M Hamilton et al.
    Unlike in early embryonic development, injured spinal cord and muscle in Xenopus laevis larvae recruit non-canonical Hedgehog signaling essential for their regeneration, while repressing Gli transcriptional activity.
    1. Computational and Systems Biology
    2. Neuroscience

    Trading mental effort for confidence in the metacognitive control of value-based decision-making

    Douglas G Lee, Jean Daunizeau
    Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.

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