2,112 results found
    1. Structural Biology and Molecular Biophysics

    Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

    Timothy Grant, Nikolaus Grigorieff
    The resolution of electron cryo-microscopy can be improved by using optimal exposure values to filter video frames.
    1. Neuroscience

    Functional reallocation of sensory processing resources caused by long-term neural adaptation to altered optics

    Antoine Barbot et al.
    Chronic exposure to poor optical quality causes a functional reallocation of sensory processing resources that favors perceptual information less affected by the eye's optics.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

    Ximena Steinberg et al.
    Single-molecule measurement of conformational dynamics using a genetically encoded fluorescent probe suggests that the selectivity filter region of TRPV1 channels undergoes dynamic motion during agonist activation.
    1. Ecology
    2. Plant Biology

    Seasonal shift in timing of vernalization as an adaptation to extreme winter

    Susan Duncan et al.
    An adaptation to extreme winter has involved a shift to autumn temperature monitoring.
    1. Biochemistry and Chemical Biology

    Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

    Vanja Panic et al.
    Mitochondrial pyruvate transport is required for brown fat thermogenesis.
    1. Microbiology and Infectious Disease

    Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

    Elizabeth A Mueller et al.
    Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
    1. Neuroscience

    Perceptual decisions are biased by the cost to act

    Nobuhiro Hagura et al.
    When choosing between stimuli, the effort required to act on the resulting decision influences the processing of the stimuli themselves.
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

    Jia Zhao et al.
    In vivo imaging reveals that gradually increased amount of glucose mediates the heterogeneous functional development of individual β-cells by activating its major downstream calcineurin/NFAT signaling pathway.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Erin D Lew et al.
    Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.

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