1,710 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen et al.
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani et al.
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Computational and Systems Biology
    2. Neuroscience

    Rats exhibit similar biases in foraging and intertemporal choice tasks

    Gary A Kane et al.
    In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.
    1. Cell Biology
    2. Developmental Biology

    Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

    Peter Walentek et al.
    At optimal concentrations, the ciliary inhibitor Cp110 promotes ciliogenesis by localization to previously uncharacterized sites at the basal body, where it recruits ciliary adhesion complexes that mediate basal body interaction with F-actin networks.
    1. Neuroscience

    Navigating the garden of forking paths for data exclusions in fear conditioning research

    Tina B Lonsdorf et al.
    Exclusion of participants in tasks with a learning element can introduce substantial bias and needs to be carefully considered and transparently reported and justified.
    1. Neuroscience

    Spatial readout of visual looming in the central brain of Drosophila

    Mai M Morimoto et al.
    In the Drosophila central brain, synaptic connectivity extracts visual-spatial information from the axons of looming sensitive LC6 neurons that terminate in a glomerulus with minimal retinotopy.
    1. Cell Biology

    Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

    Manuel Alonso Y Adell et al.
    Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.
    1. Neuroscience

    Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons

    Junchol Park, Bita Moghaddam
    Risk of punishment during reward seeking behavior is associated with a functional "disconnection" of the PFC-VTA circuit due to a transient loss of VTA-driven theta oscillation.
    1. Developmental Biology
    2. Plant Biology

    Quantitative analysis of auxin sensing in leaf primordia argues against proposed role in regulating leaf dorsoventrality

    Neha Bhatia et al.
    Top-bottom patterning of leaves is not specified by an asymmetry in the distribution of the plant hormone auxin, in contrast to a previous proposal.
    1. Genetics and Genomics

    Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

    Zhipeng Zhou et al.
    Genetic and bioinformatic analyses uncover an unexpected role for codon usage biases in regulating gene expression at the transcriptional level by suppressing premature transcription termination.

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