838 results found
    1. Neuroscience

    Optogenetic dissection of descending behavioral control in Drosophila

    Jessica Cande et al.
    Optogenetically activated individual descending neurons in Drosophila melanogaster drive varied stereotyped motor patterns that are often influenced by the animal's initial behavioral state.
    1. Neuroscience

    Optogenetic feedback control of neural activity

    Jonathan P Newman et al.
    The 'Optoclamp' is a feedback control technology that enables precise, continuously updated, closed-loop optical control of neural firing both in vitro and in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He et al.
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.
    1. Neuroscience

    Frequency-selective control of cortical and subcortical networks by central thalamus

    Jia Liu et al.
    Central thalamus relay neurons dynamically switch the activity of cortical and subcortical networks at distinct frequencies, providing a mechanism for this region's role in arousal regulation.
    1. Neuroscience

    Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation

    Mathieu Letellier et al.
    Orthogonal to traditional paradigms that manipulate neuroligin expression level, optogenetic stimulation of tyrosine phosphorylation highlights a role of the intracellular domain of endogenous neuroligin-1 in excitatory synaptic differentiation and potentiation.
    1. Neuroscience

    Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioral outputs

    Ara Schorscher-Petcu et al.
    A system to generate ‘remote touch’ in freely behaving mice can be utilized to map behavior caused by precise somatosensory inputs.
    1. Developmental Biology

    Optogenetic control of gut bacterial metabolism to promote longevity

    Lucas A Hartsough et al.
    Light controls can fine tune microbiome–host interaction to qualitatively regulate host longevity with temporal and spatial precision.
    1. Neuroscience

    Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving Drosophila

    Pierre-Yves Musso et al.
    The Sip-Triggered Optogenetic Behavior Enclosure (STROBE) produces robust behaviors via activation of peripheral or central neurons in the fly, and mimics key features of feeding driven by chemical taste ligands.
    1. Immunology and Inflammation

    Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

    O Sascha Yousefi et al.
    Controlling the duration of ligand binding to the T cell receptor by light shows that T cells discriminate stimulatory from non-stimulatory ligands by measuring the dynamics of ligand binding.
    1. Neuroscience

    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

    Qin Wang et al.
    Precise spatiotemporal optogenetic activation of ERK and AKT signaling pathways reveals neural repair mechanisms of the peripheral and central nervous systems in live Drosophila larvae.

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