Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
Cocaine elicits opposing activity changes in D1R vs D2R spiny projection neurons of the nucleus accumbens with much variability, subsequent recruitment of a subset of D1R neurons drives behavioral sensitization.
Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
Hippocampal activity during memory recall predicts a transient increase in the ratio between neocortical glutamate and GABA, thereby allowing otherwise dormant memories to be released.
A circuit between the hippocampus, nucleus reunions, and prefrontal cortex organizes information about the past, present, and future into alternating theta sequences.
Inhibitory synaptic plasticity provides a flexible and biologically plausible circuit mechanism to detect the novelty of bottom-up stimuli and to generate stimulus-specific adaptation.
A new computer controlled behavioral assay and integrated training chamber for individual Drosophila larvae shows that larvae learn all at once and create long-term memories that last overnight.
RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.
Circadian expression of cone visual transduction genes and corresponding proteins correlates with circadian changes in photoresponse kinetics and visual behavior, linking circadian gene expression with physiological and behavioral rhythmicity.
