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    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Evolutionary Biology

    New fossils of Australopithecus sediba reveal a nearly complete lower back

    Scott A Williams, Thomas Cody Prang ... Lee R Berger
    Newly recovered lumbar vertebrae belonging to Malapa Hominin 2, an adult female of the fossil hominin species Australopithecus sediba, demonstrate that this individual was adapted to upright posture and bipedal locomotion but also had adaptations for climbing in trees.
    1. Genetics and Genomics
    2. Evolutionary Biology

    The Primate Major Histocompatibility Complex: An Illustrative Example of Gene Family Evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Evolutionary Biology

    Evolution: Mapping the ancestry of primates

    Ignacio Martínez, Mercedes Conde-Valverde
    Structures in the inner ear can help determine the evolutionary relationship between extinct and living primates.
    Version of Record
    Insight
    1. Evolutionary Biology

    Transition to siblinghood causes a substantial and long-lasting increase in urinary cortisol levels in wild bonobos

    Verena Behringer, Andreas Berghänel ... Gottfried Hohmann
    In wild bonobos, sibling birth induced a sudden increase in urinary cortisol levels in the older offspring, a physiological response that occurred in all subjects and was independent of their age.
    1. Microbiology and Infectious Disease

    Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus

    Jenna M Gaska, Metodi Balev ... Alexander Ploss
    Incompatibilities between the viral replication machinery and orthologs of the essential host factor cyclophilin A (CypA) contribute to the narrow host range of hepatitis C virus.
    1. Evolutionary Biology

    Gene Transfer: Adapting for life in the extreme

    Carolin M Kobras, Daniel Falush
    Red algae have adapted to extreme environments by acquiring genes from bacteria and archaea.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Evolutionary Biology

    Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Tracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammals

    William E Diehl, Nirali Patel ... Welkin E Johnson
    Endogenous virus sequences in the genomes of modern mammals reveal the global spread of an ancient virus lineage, including frequent interspecies transmission, adaptation, and emergence spanning several million years of mammalian evolution
    1. Evolutionary Biology

    A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

    Michelle C Ward, Yoav Gilad
    Evolutionarily conserved hypoxic stress response genes are depleted for association with expression quantitative trait loci.