92 results found
    1. Neuroscience

    Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits

    Marios C Panayi, Simon Killcross
    The rodent orbitofrontal cortex makes functionally distinct contributions to flexible behavioural control, even within a single putative orbitofrontal subregion, which has important implications for establishing homology between rodent and primate orbitofrontal cortex.
    1. Neuroscience

    Covert shift of attention modulates the value encoding in the orbitofrontal cortex

    Yang Xie et al.
    The orbitofrontal neurons only encode the value of one item, which may be selected by covert attention combining factors of value and visual salience, suggesting a sequential processing mechanism of value information in the brain.
    1. Neuroscience

    Specialized areas for value updating and goal selection in the primate orbitofrontal cortex

    Elisabeth A Murray et al.
    Within the monkey orbitofrontal cortex, a posterior part learns new values, whereas an anterior part translates this knowledge into advantageous decisions.
    1. Neuroscience

    Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty

    Alexandra Stolyarova, Alicia Izquierdo
    Rat orbitofrontal cortex is required to accurately represent outcome distributions, whereas basolateral amygdala is necessary for the facilitation of learning in response to surprising events.
    1. Neuroscience

    Instructed knowledge shapes feedback-driven aversive learning in striatum and orbitofrontal cortex, but not the amygdala

    Lauren Y Atlas et al.
    While the striatum and orbitofrontal cortex learn about threats through verbal warnings, the amygdala learns only from direct experience, suggesting that the amygdala forms part of a specialized threat detection system.
    1. Neuroscience

    Medial orbitofrontal inactivation does not affect economic choice

    Matthew PH Gardner et al.
    Inactivation of the medial orbitofrontal cortex using an optogenetic approach did not affect behavior in rats on an iconic economic choice task.
    1. Neuroscience

    A thalamocortical circuit for updating action-outcome associations

    Virginie Fresno et al.
    Disconnection of the orbitofrontal cortex from the submedius nucleus but not the mediodorsal thalamus prevented rats to respond adaptively following action-outcome reversal, showing differential involvement of these thalamocortical circuits.
    1. Neuroscience

    Reward-based training of recurrent neural networks for cognitive and value-based tasks

    H Francis Song et al.
    A two-part neural network models reward-based training and provides a unified framework in which to study diverse computations that can be compared to electrophysiological recordings from behaving animals.
    1. Neuroscience

    Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

    Wei Cheng et al.
    The findings have a major impact in understanding the different reward systems involved in two types of addictive behavior, and these advances have implications for prevention and treatment.
    1. Neuroscience

    Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task

    Brian F Sadacca et al.
    Neural activity in the orbitofrontal cortex (OFC) represents incidental stimulus-stimulus associations, providing additional evidence for OFC having a role in cognition beyond functions centered on processing value or biological significance.

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