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Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling
Hao Wu et al.
The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.
Chromosomes and Gene Expression
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
Anca M Farcas et al.
A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
Structural Biology and Molecular Biophysics
Myosin motors fragment and compact membrane-bound actin filaments
Sven K Vogel et al.
A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
Quantification of gait parameters in freely walking wild type and sensory deprived
César S Mendes et al.
Novel imaging experiments suggest that fruit flies modify their neural circuitry for walking at slow, medium and fast speeds, and that proprioception is not essential for coordinated walking.
Dual functions of TAF7L in adipocyte differentiation
Haiying Zhou et al.
A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
Biochemistry and Chemical Biology
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
Rati Verma et al.
The enzyme that collaborates with ubiquitin ligases to promote the release of defective polypeptides from stalled ribosomes in a process named ribosome-associated degradations has been identified as the ATPase Cdc48.
A virus responds instantly to the presence of the vector on the host and forms transmission morphs
Alexandre Martinière et al.
Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.
Recognition of familiar food activates feeding via an endocrine serotonin signal in
Bo-mi Song et al.
The nematode worm
consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.
Hierarchical organization of context in the hippocampal episodic code
Neurons in the hippocampus modulate the rates at which they fire, and the locations in which they fire, so as to encode the information that is central to forming memories about personal experiences.
Mitotic spindle scaling during
development by kif2a and importin α
Jeremy D Wilbur, Rebecca Heald
An interaction between two proteins enables the spindle—the structure that segregates chromosome pairs during mitosis—to change size as cells divide.
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