4,600 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert et al.
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Structural Biology and Molecular Biophysics

    A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation

    Yanyan Liu et al.
    Small Rho GTPases confer up- and downregulation in mammalian plexin signaling by differential interactions with cell membrane.
    1. Neuroscience

    Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans

    Xi Chen et al.
    Plexin controls the spatial distribution of synapses by locally inhibiting Rap2 small GTPase activity along the axon, and a Rap2 effector, TNIK, which also plays a key role in inhibiting synapse number.
    1. Immunology and Inflammation
    2. Neuroscience

    Peripherally administered orexin improves survival of mice with endotoxin shock

    Yasuhiro Ogawa et al.
    When the neuropeptide orexin is peripherally administered in mice with septic shock, it penetrates the blood-brain barrier and acts in the brain to improve survival through multiple autonomic and neuroendocrine pathways.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

    Yuxiao Wang et al.
    The crystal structures of the intracellular part of the plexin receptor in the active dimer form, and its complex with a key downstream signalling protein Rap, provide insights into how plexin initiates a signalling cascade involved in axon guidance.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet et al.
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Neuroscience

    DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation

    Laura Morcom et al.
    Incomplete interhemispheric fissure remodelling determines corpus callosum size in humans and BTBR N2 mice that carry a deletion in Draxin.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The role of Rif1 in telomere length regulation is separable from its role in origin firing

    Calla B Shubin, Carol W Greider
    Telomere length is linked to DNA replication, and we found excessive telomeric origin firing caused by several distinct mutants did not lengthen telomeres, narrowing possible mechanisms.
    1. Neuroscience

    Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy

    Chi Jung Hung et al.
    New transgenic mice, which can be ablated both orexin neurons and MCH neurons, showed new brain state and revealed functional interaction that MCH neurons have protective role in narcolepsy symptoms.

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