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    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction

    Cherilyn A Elwell et al.
    Structure of a pathogen effector complexed to Sorting Nexin 5 reveals an evolutionarily conserved interface that is required for retromer-dependent host restriction.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

    Jean-Michel Arbona et al.
    The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.
    1. Neuroscience

    Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

    Ted M Hsu et al.
    A communication pathway linking memory processing and feeding behavior exists between the gut hormone ghrelin, the hippocampus and the hypothalamic neuropeptide orexin.
    1. Structural Biology and Molecular Biophysics

    The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA

    Dahai Gai et al.
    A structural study reveals how the simian virus 40 Large-T hexamer helicase interacts with its origin DNA and partially melts the origin double-stranded DNA within the hexamer channel.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structure of the active form of human origin recognition complex and its ATPase motor module

    Ante Tocilj et al.
    The human Origin Replication Complex is shaped as a shallow corkscrew in a classic AAA+ organization reminiscent of clamp loader complexes with highly controlled ATPase activity as exemplified by Meier-Gorlin syndrome mutations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor

    Richard Benton et al.
    Comparative genomics and three-dimensional protein modelling identify homologs of insect chemosensory receptors in unicellular eukaryotes and plants.
    1. Biochemistry and Chemical Biology
    2. Ecology

    De novo synthesis of a sunscreen compound in vertebrates

    Andrew R Osborn et al.
    Many vertebrates are able to synthesize a sunscreen compound de novo and the pathway involved can be used for heterologous production of the compound in yeast.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting geographic location from genetic variation with deep neural networks

    CJ Battey et al.
    Neural networks allow fast and accurate prediction of individual spatial locations from genotypes or sequencing data.
    1. Biochemistry and Chemical Biology

    An explanation for origin unwinding in eukaryotes

    Lance D Langston, Michael E O'Donnell
    CMG helicase translocates with force while encircling duplex DNA, enabling two opposing CMG complexes at an origin to melt the duplex and switch to encircling separate single strands.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul et al.
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.