316 results found
    1. Neuroscience

    Principles of operation of a cerebellar learning circuit

    David J Herzfeld et al.
    Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
    1. Ecology

    Modelling the climatic suitability of Chagas disease vectors on a global scale

    Fanny E Eberhard et al.
    The global ensemble forecasting niche modelling of 11 vector competent triatomine species revealed climatic suitable regions outside their native distribution including the cosmopolitan vector Triatoma rubrofasciata.
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong et al.
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Neuroscience

    A role for CIM6P/IGF2 receptor in memory consolidation and enhancement

    Xiao-Wen Yu et al.
    Cation-independent-mannose-6-phosphate-receptor, or insulin-like-growth-factor-2-receptor (CIM6P/IGF2R) expressed in the hippocampus controls the protein metabolism regulated by learning and required for memory consolidation, and is also a key mechanism for memory enhancement.
    1. Evolutionary Biology
    2. Neuroscience

    CNGA3 acts as a cold sensor in hypothalamic neurons

    Viktor V Feketa et al.
    CNGA3 is a cold-potentiated ion channel that confers cold sensitivity to mouse hypothalamic neurons, whereas CNGA3 from hibernating ground squirrels is cold-insensitive.
    1. Developmental Biology

    Chloride channels regulate differentiation and barrier functions of the mammalian airway

    Mu He et al.
    The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

    Aaron M Allen et al.
    A single-cell atlas of the adult fly VNC charts the types and properties of cells for future studies of brain development and function.
    1. Evolutionary Biology

    Phenotypic plasticity as a mechanism of cave colonization and adaptation

    Helena Bilandžija et al.
    Astyanax mexicanus surface-dwelling fish exposed to complete darkness develop many traits resembling cavefish adaptations by phenotypic plasticity in a single generation.
    1. Neuroscience

    Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

    Janus RL Kobbersmed et al.
    Heterogeneous distances between vesicles and Ca2+-channels make synapses prone to short-term depression, however, Ca2+-dependent increases in the number of release-ready vesicles supports facilitation even with broadly distributed vesicle:Ca2+-channel distances.
    1. Neuroscience

    Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

    Mirko Luoni et al.
    Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.

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