824 results found
    1. Cell Biology

    Quantitative regulation of the dynamic steady state of actin networks

    Angelika Manhart, Téa Aleksandra Icheva ... Alex Mogilner
    Cells are able to control the actin network length and steering by adjusting geometric, structural, or biochemical parameters such as ADF/Cofilin and actin concentrations, and network width.
    1. Developmental Biology

    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

    Namsuk Kim, Yan Li ... Won-Jong Oh
    Repulsive guidance cues enhance a dual-functioning axonal trafficking facilitator, allowing navigating axons to ensure proper pathfinding by coordinating positive extension and negative steering during nervous system development.
    1. Chromosomes and Gene Expression

    Identification of epigenetic modulators as determinants of nuclear size and shape

    Andria C Schibler, Predrag Jevtic ... Tom Misteli
    Chromatin modifiers shape nuclear morphology.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presence

    Monica Salinas-Pena, Elena Rebollo, Albert Jordan
    Imaging analysis confirms ChIP-Seq data on the distinct genomic distribution of histone H1 variants in AT-rich, nuclear peripheral regions (H1.2, H1.3, H1.5, H1.0) or GC-rich, throughout the nucleus (H1.4, H1X).
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers, Brent W Simpson, M Stephen Trent
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Ecology

    Dynamic metabolic exchange governs a marine algal-bacterial interaction

    Einat Segev, Thomas P Wyche ... Roberto Kolter
    Physical and chemical interactions with bacteria influence the life and death of Emiliania huxleyi, a bloom-forming micro-alga important in global biogeochemical cycles.
    1. Cancer Biology
    2. Medicine

    Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis

    Xinbo Qiao, Yixiao Zhang ... Caigang Liu
    CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
    1. Cancer Biology

    Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

    Phaedra C Ghazi, Kayla T O'Toole ... Martin McMahon
    Inhibiting KRASG12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRASG12C-driven lung cancer in preclinical models of lung cancer.
    1. Developmental Biology

    The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling

    Shi-Li Xia, Meng Li ... Yingchuan B Qi
    Identified as a binding factor of transcription factor MYRF, the LRR-TM protein PAN-1 promotes the cell-membrane localization and nuclear translocation of MYRF, which drives synaptic rewiring in Caenorhabditis elegans.
    1. Cell Biology

    AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

    Arnold Y Seo, Pick-Wei Lau ... Jennifer Lippincott-Schwartz
    Upon AMPK activation by acute glucose restriction, Atg14p shifts its distribution from ER exit sites to liquid-ordered membrane domains on the vacuolar surface where, together with Atg6p, it facilitates LD-specific autophagy (i.e., microautophagy of lipid droplets) for energy production and long-term survival of starved cells.

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