72 results found
    1. Developmental Biology

    Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features

    Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

    Joseph Hanna, Yacine Touahri ... Carol Schuurmans
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai, Maria Trexler ... László Patthy
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

    Merrick D Pierson Smela, Christian C Kramme ... George M Church
    Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    CHD-associated enhancers shape human cardiomyocyte lineage commitment

    Daniel A Armendariz, Sean C Goetsch ... Gary C Hon
    Single-cell screens during human cardiomyocyte (CM) differentiation reveal that perturbation of congenital heart defect-linked enhancers/genes causes deficient CM differentiation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

    Takeshi Katsuda, Juntaro Matsuzaki ... Takahiro Ochiya
    Human chemically induced liver progenitors (hCLiPs), which are generated from primary human hepatocytes, exhibit the potential to repopulate injured livers of host mice with efficiency > 90%.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

    Mirna Marinić, Katelyn Mika ... Vincent J Lynch
    The transcription factor HAND2 evolved uterine expression during the origins of pregnancy and may be important for maternal-fetal immune signaling and parturition.
    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan, Yun-Yu Tseng ... Oliver Florey
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    1. Developmental Biology

    Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

    Bryan Marsh, Yan Zhou ... Robert Blelloch
    Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.

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