602 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

    Allen Wang et al.
    Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.
    1. Stem Cells and Regenerative Medicine

    Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells

    Balyn W Zaro et al.
    Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.
    1. Ecology
    2. Physics of Living Systems

    Efficient mate finding in planktonic copepods swimming in turbulence

    François-Gaël Michalec et al.
    Calanoid copepods achieve efficient mate finding in turbulence through active swimming and turbulence advection, indicating that reproduction is not restricted to spatial and temporal windows of calm hydrodynamic conditions.
    1. Cell Biology

    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation

    Maria Fomicheva, Ian G Macara
    TRAF3, a negative regulator of noncanonical NF-κB signaling, maintains epithelial cell quiescence at confluence, and its loss triggers upregulation of immunity genes and prevents entry into G0 at high cell density.
    1. Neuroscience

    Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer’s disease related oligomers

    Tobias Lieblein et al.
    Monitoring the formation of two distinct arrangements in early amyloid-ß aggregation by mass spectrometry and ion mobility allows determination of the effect of potential drug candidates.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

    Damien Lemoine et al.
    A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
    1. Plant Biology

    The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation

    M Rosario Ramírez-Flores et al.
    Heritable variation in the benefit maize plants receive from arbuscular mycorrhizal fungi supports the feasibility of breeding crops to optimize use of this ancient symbiosis.
    1. Developmental Biology

    Single nuclei RNA-seq of mouse placental labyrinth development

    Bryan Marsh, Robert Blelloch
    A time-course of single nuclei RNA-seq of the mouse placenta identifies trophoblast subtypes and the genes, signaling events, and transcriptional networks important for their differentiation, maintenance, and function.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Cytotoxic T cells swarm by homotypic chemokine signalling

    Jorge Luis Galeano Niño et al.
    Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic signal in a positive feedback loop.
    1. Cancer Biology

    eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

    Hang Ruan et al.
    Genetic and transcriptomic analyses revealed that eIF4E S209 phosphorylation enables Myc and mutant KRAS cooperation in colon cancer through stress- and glutamine-dependent growth and addiction.

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