159 results found
    1. Structural Biology and Molecular Biophysics

    Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme

    Samuel Thompson et al.
    Changes to cellular protein homeostasis reveal widespread advantageous effects of destabilizing mutations, opening the possibility to switch mutational landscapes back-and-forth from permissive to restrictive.
    1. Cancer Biology
    2. Cell Biology

    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

    Ashna Alladin et al.
    The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.
    1. Immunology and Inflammation

    Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells

    Sabrina Bianca Bennstein et al.
    Neonatal ILC1-like cells are functionally immature but have the unique potential to generate NK cells characterized by downregulation of NKG2A and a highly diverse KIR receptor repertoire.
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells

    Nalin Leelatian et al.
    A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
    1. Cell Biology
    2. Immunology and Inflammation

    Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Emma J Fenech et al.
    Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi et al.
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez et al.
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

    Stacie A Clark et al.
    Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet et al.
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.

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