32 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

    Huan Liu et al.
    Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
    1. Neuroscience

    Cerebellar involvement in an evidence-accumulation decision-making task

    Ben Deverett et al.
    In a new evidence-accumulation decision-making task, activity of the lateral posterior cerebellum is necessary for accurate performance, and somatic and dendritic activity in Purkinje cells contains choice/evidence and error-related information.
    1. Neuroscience

    Uncovering the functional anatomy of the human insula during speech

    Oscar Woolnough et al.
    Direct insular recordings in humans reveal that contrary to several prominent models of speech production, it is not engaged in pre-articulatory planning, but in auditory and somatosensory components of speech.
    1. Neuroscience

    Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

    Takayuki Yamashita, Carl CH Petersen
    A learning-induced, motor-related, projection-specific signal from S1 to S2 accompanies reward-based-learning of a goal-directed sensorimotor transformation of whisker sensation into licking motor output.
    1. Neuroscience

    Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

    Narendra Mukherjee et al.
    Primary taste cortex does far more than code tastes by turning taste codes into motor commands via population dynamics.
    1. Neuroscience

    Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis

    Sergey D Stavisky et al.
    Neurons in human dorsal motor cortex, an area involved in controlling arm and hand movements, are also active – and show similar ensemble dynamics – during speaking.
    1. Neuroscience

    Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

    Michael A Gaffield et al.
    In behaving mice, inhibition from molecular layer interneurons attenuates excitation of Purkinje cells by parallel fibers and suppresses their ability to enhance climbing fiber-triggered dendritic Ca2+ responses.
    1. Biochemistry and Chemical Biology

    Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

    Rima S Chakrabarti et al.
    Accessible cholesterol levels in human red blood cells were found to be stable within individuals but vary >10-fold among individuals and this variability may contribute to differences in cholesterol trafficking among tissues.
    1. Neuroscience

    Orofacial Coordination: How do we walk and chew gum at the same time?

    Philippe Morquette, Arlette Kolta
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    1. Neuroscience

    Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

    Sebastian Korb et al.
    Administration of dopamine and opioid receptor antagonists resulted in reduced reward anticipation (effort and increased negative facial reactions), but only administration of opioid antagonists resulted in reduced liking (facial reactions).

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