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The shared capacity of stem cells to recapitulate initial body plan formation in vitro without species-specific cues, suggests the existence of alternative, evolutionarily conserved developmental trajectories.

Phylogenetic, biochemical, and genetic techniques reveal a novel and ancient member of the Perilipin family, termed Plin6, that functions to concentrate and traffic lipophilic skin pigment in teleost fish.

The absence of DMRT1 induces a male-to-female sex reversal in XY rabbits and complete infertility in both sexes.

Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.

Zebrafish scales depend on interactions among Wnt, Ectodysplasin and Hedgehog signaling pathways similar to those underlying feathers, teeth and hair follicles, suggesting a deep homology of ectodermal appendages in vertebrates.

A novel in vivo strategy for reversible, multiplexed control of circulating hormone expression levels, achieved by combining genome-editing and intramuscular electroporation of fluorescently tagged hormones in the naturally short-lived turquoise killifish.

Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.

A shift in antero-posterior positional information may contribute to the fin-to-limb transformation.