902 results found
    1. Cancer Biology

    Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

    Takashi Ogino et al.
    The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.
    1. Developmental Biology
    2. Neuroscience

    Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

    Cassandra B Klune et al.
    An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.
    1. Developmental Biology

    Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development

    Markus Frederik Schliffka et al.
    During mouse preimplantation development, the complete loss of actomyosin contractility abolishes cytokinesis but not apico-basal polarisation, lineage specification, or fluid accumulation, which are the critical steps to the formation of the blastocyst.
    1. Neuroscience

    Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans

    Michael Schaum et al.
    Response inhibition is initiated by the right inferior frontal gyrus (rIFG), and stopping performance is predicted by beta-band power as well as beta-band connectivity between rIFG and pre-supplementary motor area.
    1. Neuroscience

    Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

    André M Bastos et al.
    Understanding how general anesthesia changes neural dynamics in the cortex and thalamus can lead to its safer use and shed light on the nature of consciousness.
    1. Medicine
    2. Neuroscience

    The mechanism underlying transient weakness in myotonia congenita

    Jessica H Myers et al.
    Transient weakness in myotonia congenita is caused by depolarization secondary to activation of persistent Na+ current in skeletal muscle.
    1. Physics of Living Systems

    The biomechanical role of extra-axonemal structures in shaping the flagellar beat of Euglena gracilis

    Giancarlo Cicconofri et al.
    The 'spinning lasso' geometry of Euglena's beating flagellum is revealed, and a model based on the antagonistic forces exchanged by axoneme and paraflagellar rod is proposed to explain its emergence.
    1. Neuroscience

    Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

    Mahmood S Hoseini et al.
    Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.
    1. Neuroscience

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

    Przemyslaw Jarzebowski et al.
    Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
    1. Physics of Living Systems

    Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

    Rinat Arbel-Goren et al.
    Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.

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