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    1. Cell Biology

    Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion

    Caroline Lekszas et al.
    The first human TANGO1-associated syndromal disease manifests as impaired collagen secretion, highlighting the importance of TANGO1 in human pathophysiology.
    1. Stem Cells and Regenerative Medicine

    Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway

    Nguyen PT Huynh et al.
    Bioinformatic analysis of mesenchymal stem cell chondrogenesis identified a novel long noncoding RNA, GRASLND, which suppresses interferon signaling and enhances chondrogenesis.
    1. Cell Biology
    2. Developmental Biology

    YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

    Kishor K Sivaraj et al.
    The interplay between the transcriptional co-regulators YAP1/TAZ and the hypoxia-controlled transcription factor HIF1α differentially regulates endothelial cell behavior in the hypoxic environment of bone compared to other organs.
    1. Stem Cells and Regenerative Medicine

    Distinct skeletal stem cell types orchestrate long bone skeletogenesis

    Thomas H Ambrosi et al.
    Functional and molecular analyses of two distinct skeletal stem cell populations establish the important role of stem cell diversity that provides a framework for novel investigations into skeletal biology.
    1. Ecology
    2. Neuroscience

    Dopamine drives Drosophila sechellia adaptation to its toxic host

    Sofía Lavista-Llanos et al.
    The insect dopaminergic system serves an important function in the regulation of ontogenesis and early development, contributing to the evolutionary processes that limit the ecological niche of Drosophila sechellia.
    1. Developmental Biology
    2. Plant Biology

    A digital 3D reference atlas reveals cellular growth patterns shaping the Arabidopsis ovule

    Athul Vijayan et al.
    Deep imaging, machine-learning-based segmentation, and tissue annotation resulted in a developmental series of 3D digital ovules with cellular resolution allowing next-level analysis of the ontogenesis of this complex organ.
    1. Neuroscience

    Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries

    Sebastian Ocklenburg et al.
    Gene expression asymmetries in fetal spinal cord are triggered by epigenetic mechanisms suggesting that handedness has a spinal instead of a cortical origin.
    1. Developmental Biology

    Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development

    Filomena Caccavale et al.
    Previously undescribed morphogenetic and developmental mechanisms unravel that the cooperation of two ancient signaling pathways, nitric oxide and retinoic acid, is essential to build a chordate embryo.
    1. Cell Biology

    GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation

    Ming Li et al.
    GAS5 is related to osteoporosis by regulating the differentiation of bone marrow stromal cells that acts as a promising treatment target for osteoporosis.
    1. Developmental Biology

    Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis

    Xia Han et al.
    Identification of heterogenous cranial neural crest (CNC)-derived cell populations and their roles in guiding craniofacial muscle development through cell-cell interactions.