1,067 results found
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Evolutionary pathways of repeat protein topology in bacterial outer membrane proteins

    Meghan Whitney Franklin et al.
    There is a strand-based evolutionary mechanism for the diversification of outer membrane proteins, which has implications for how repeat proteins are created and for how outer membrane proteins fold.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.
    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.
    1. Cell Biology

    A protein quality control pathway at the mitochondrial outer membrane

    Meredith B Metzger et al.
    Temperature-sensitive mitochondrial outer membrane proteins used as novel quality control substrates reveal a unique mitochondria-associated degradation pathway consisting of both cytosolic and mitochondrial ubiquitin-proteasome system machinery.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Direct live imaging of cell–cell protein transfer by transient outer membrane fusion in Myxococcus xanthus

    Adrien Ducret et al.
    Physical contact between two Myxococcus xanthus cells is sufficient to fuse their outer membrane transiently and exchange outer membrane proteins and lipids at high efficiency.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry

    Shuhua Thong et al.
    Auxiliary proteins play functional roles in modulating the assembly and activity of a non-canonical ABC transporter that is important for the maintenance of outer membrane lipid asymmetry.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Protein Evolution: Building bigger beta-barrels

    Vikas Nanda
    The range of barrel-shaped proteins found in the outer membrane of certain bacteria evolved through multiple pathways.
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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

    James Lee et al.
    Outer membrane β-barrel proteins in Gram-negative bacteria are assembled within the lumen of the BamA β-barrel.
    1. Structural Biology and Molecular Biophysics

    Allosteric signalling in the outer membrane translocation domain of PapC usher

    Irene Farabella et al.
    Input from computational models has enabled the detection of allosteric communication that modulates the gating mechanism of a bacterial outer-membrane protein.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

    Xiaoke Chi et al.
    The C-terminal membrane binding domain of Bim is shown to interact with and activate Bim enabling it to kill cells not dependent on anti-apoptotic proteins for survival.

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