New views on the relevance of bone morphogenetic protein signalling fine tuning in the cardiac neural crest cells for the heart outflow tract septation and the formation of the great arteries.
Alk5/TGF-β signaling is required in the endothelium to orchestrate zebrafish cardiac outflow tract morphogenesis, regulating smooth muscle cell and extracellular matrix organization.
High resolution in vivo imaging of the zebrafish heart morphogenesis allows quantitative testing of the impact of stretch sensitive channels during outflow tract valve development.
The discovery of a fossil heart in Rhacolepis buccalis demonstrates that it is possible to scrutinize the fossil record for important clues on cardiac structure and evolution.
The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
Identification of a novel source of progenitor cells that form arterial valve leaflets and that, when disrupted, can lead to bicuspid arterial valve, the most common human cardiac malformation.
Cardiac progenitors remain undifferentiated and expansive in the second pharyngeal arch that serves as a microenvironment, and Numb and Numblike are required for their renewal.
The transcription factor Meis1 is a dedicated maintenance factor for sympathetic neurons and controls the expression of key genes involved in endosome trafficking.
Analyses of human stem cells with distinct GATA6 mutations revealed a spectrum of molecular responses that drive isolated congenital heart disease or the co-occurrence of pancreas and diaphragm malformations.