ADGRG2, an orphan GPCR, when coupled to CFTR via a regional Gq signaling on the apical membrane, acts to regulate efferent duct fluid reabsorption making it essential for male fertility.

Structurally divergent bacterial-like mechanosensitive channels control multiple cellular functions in protozoan parasites.

T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.

A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.

The pairing of chemogenetic and electrophysiological approaches reveals mechanisms by which cholinergic synapses modulate the final motor output of the nervous system.

Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.

Serotonin changes passive membrane properties in prefrontal fast-spiking interneurons to affect not only neuronal excitability but also the temporal filtering of synaptic inputs with a preference for gamma-frequency summation.

Electrophysiological experiments, Ca²⁺ imaging, and behavioral studies in mice identify the TRPM3 ion channel as a novel target of G-protein βγ subunits.

Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.