2,691 results found
    1. Neuroscience

    A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

    David A Crowe, Andrew Willow ... Bagrat Amirikian
    Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
    1. Genetics and Genomics
    2. Neuroscience

    Feeding: How specific molecules can lead to overeating

    María Gabriela Blanco, Diego Rayes
    A molecular pathway involving compounds found in processed foods and biogenic amines increases food intake and aging in the roundworm C. elegans.
    Version of Record
    Insight
    1. Neuroscience

    Reciprocally inhibitory circuits operating with distinct mechanisms are differently robust to perturbation and modulation

    Ekaterina Morozova, Peter Newstein, Eve Marder
    Nuanced changes in the mechanism of oscillation in reciprocally inhibitory circuits can profoundly alter the circuit stability in response to perturbations and inputs.
    1. Neuroscience

    Octopamine integrates the status of internal energy supply into the formation of food-related memories

    Michael Berger, Michèle Fraatz ... Henrike Scholz
    Intense starvation with high internal energy levels results in remarkably stable food-related memories that persist beyond actual food intake and are associated with overeating.
    1. Ecology

    Countercurrent heat exchange and thermoregulation during blood-feeding in kissing bugs

    Chloé Lahondère, Teresita C Insausti ... Claudio R Lazzari
    A novel thermoregulatory mechanism in blood-sucking insects, vectors of human disease, is described using a functional-morphological approach.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4

    Christopher I Murray, Maartje Westhoff ... David Fedida
    The IKs potassium channel complex displays functional flexibility that depends on the ratio of its constituent KCNQ1 and KCNE1 protein subunits.
    1. Neuroscience

    Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

    Christina E May, Julia Rosander ... Monica Dus
    Taste-dependent satiation, which induces proper cessation of feeding in mammals as well as insects, is weakened by sugar-diet-driven taste impairment in the fruit fly.
    1. Neuroscience

    Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex

    Shinya Ohara, Stefan Blankvoort ... Menno P Witter
    The connection from layer Vb-to-Va neurons, a key component of the canonical hippocampal-cortical output circuit, which is allegedly crucial for memory consolidation, is relatively stronger in lateral entorhinal cortex compared with the medial entorhinal cortex, thus suggesting different operating principles.
    1. Cell Biology

    Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9

    Juliana S Capitanio, Ben Montpetit, Richard W Wozniak
    Mechanistic insight into the role of intranuclear Nup98 in gene expression is revealed by functional interactions with the helicase DHX9.
    1. Physics of Living Systems

    Muscle-specific economy of force generation and efficiency of work production during human running

    Sebastian Bohm, Falk Mersmann ... Adamantios Arampatzis
    During human running, the soleus muscle was found to operate as work generator under optimal conditions for work production (high force-length potential and enthalpy efficiency) while the vastus lateralis promoted tendon energy storage and economical force generation (high force-length-velocity potential).

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