Katarzyna Nowak, Gerhard Seisenbacher ... Hugo Stocker
Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations.
Fibroblast growth factor 21 blocks hepatic lipid influx and accumulation, prevents Kupffer cell activation, and inhibits the formation of hepatic lipid- and scar-associated macrophages, thereby likely inhibiting fibrogenesis in nonalcoholic steatohepatitis in humanized APOE*3-Leiden.CETP mice.
Ana Patrícia Graça, Vadim Nikitushkin ... Gerald Lackner
The mftG gene, present in the majority of mycofactocin gene clusters, encodes an oxidoreductase that facilitates ethanol utilization by reoxidation of mycofactocins and channeling electrons towards the respiratory chain.
Articles about doing a PhD tend to focus on the difficulties faced by research students: here we argue that the scientific community should also highlight the positive elements of the PhD experience.
Mathematical analyses explore the impact of co-substrate cycling on the dynamics of cellular metabolism, and demonstrate that these dynamics can limit cellular fluxes and that co-substrate pool dynamics can be regulated to regulate fluxes.
A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.
