129 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

    Menghan Liu et al.
    A novel multi-omics framework revealed the taxonomic contribution to microbiota oxalate, demontrated O. formigenes as the dominating taxon transcriptionally, and identified specific IBD cohort at risk for oxalte toxicity.
    1. Cell Biology

    Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response

    Esti Singer et al.
    The dual function of an ancient prokaryotic enzyme, which is linked to specific metabolite signals, may have been the evolutionary driving force behind its dual localization in eukaryotes.
    1. Cancer Biology

    Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

    Shawn McGuirk et al.
    Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

    Ross T Lindsay et al.
    β-Hydroxybutyrate accumulates in the perfused rat heart during ischaemia, driven by flux through both HMGCS and SCOT, with implications for functional recovery.
    1. Biochemistry and Chemical Biology

    Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

    Vanja Panic et al.
    Mitochondrial pyruvate transport is required for brown fat thermogenesis.
    1. Medicine

    High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

    Ok-Hee Kim et al.
    A high-phytate-low Ca2+ diet causes crystal nephropathies, renal phosphate wasting, and bone disease in rats, whereas high Ca2+ intake ameliorates the detrimental effects of a high-phytate diet.
    1. Cell Biology
    2. Cancer Biology

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao et al.
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Plant Biology

    Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

    Alexey Shapiguzov et al.
    Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.
    1. Genetics and Genomics
    2. Medicine

    EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

    Jeremie Gautheron et al.
    Disruption of epoxide hydrolysis inducing oxidative stress and cellular senescence is a novel mechanism responsible for lipoatrophic monogenic diabetes.
    1. Cancer Biology

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Allison N Lau et al.
    Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.

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