696 results found
    1. Biochemistry and Chemical Biology

    Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

    Andrew Melber et al.
    Mitochondrial proteins Nfu1 and BolA3 mediate the transfer of preformed [4Fe-4S] clusters within the mitochondria to recipient proteins to shield clusters from oxidative damage during transfer.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

    Tom Killelea et al.
    An investigation into 8-oxodeoxguanosine bypass by archaeal DNA polymerases.
    1. Cell Biology

    DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

    Brittany J Belin et al.
    An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

    Agnes Ulfig et al.
    N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
    1. Genetics and Genomics

    Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

    David A Knowles et al.
    Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.
    1. Neuroscience

    Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells

    Christina Chatzi et al.
    Neural progenitors reside in relative low oxygen in the subgranular zone (SGZ), and the higher tissue oxygen levels that these cells must face as they migrate away from the hypoxic areas and differentiate appear to cause oxidative damage and an early phase of cell death.
    1. Developmental Biology

    NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

    Dandan Han et al.
    NEIL DNA glycosylases are required to counteract oxidative base damages within the mitochondrial genome to safeguard neural crest cell differentiation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Siglec receptors impact mammalian lifespan by modulating oxidative stress

    Flavio Schwarz et al.
    By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
    1. Cell Biology

    Aging: A new answer to old questions

    Yves Barral
    Insight
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Hold your breath!

    Katharina Lust, Joachim Wittbrodt
    Insight
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