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Page 3 of 142
    1. Microbiology and Infectious Disease

    The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

    Louise Tzung-Harn Hsieh, Belinda S Hall ... Rachel E Simmonds
    The secreted toxin mycolactone has severe effects on the cells lining blood vessels that will play a critical role in the development of swelling in Buruli ulcer disease.
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Microbiology and Infectious Disease

    Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria

    Sromona D Mukherjee, Carlos A Batagello ... Aaron W Miller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae

    Jiadai Huang, Fang Chen ... Xin Deng
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan M Shugarts Devanapally, Aishwarya Sathya ... Antony M Jose
    Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes in gene expression.
    1. Cell Biology
    2. Genetics and Genomics

    The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

    Adam D Longhurst, Kyle Wang ... David P Toczyski
    An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.
    1. Cancer Biology

    Deuterium Metabolic Imaging Phenotypes Mouse Glioblastoma Heterogeneity Through Glucose Turnover Kinetics

    Rui V Simões, Rafael N Henriques ... Noam Shemesh
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Novel Mechanism for Tubular Injury in Nephropathic Cystinosis

    Swastika Sur, Maggie Kerwin ... Minnie M Sarwal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Kaho Cho ... Michael D Kornberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response

    Ling Cheng, Ian Meliala ... Mikael Björklund
    A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation mechanisms.