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Page 4 of 142
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

    Samantha Ebersoll, Marta Bogacz ... R Luise Krauth-Siegel
    African trypanosomes have a trypanothione-based mitochondrial thiol redox metabolism.
    1. Developmental Biology

    Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

    Seok Hee Lee, Xiaowei Liu ... Paolo F Rinaudo
    In vitro fertilization-conceived murine embryos show evidence of oxidative and metabolic stress with alteration in lactic acid metabolism.
    1. Cell Biology
    2. Computational and Systems Biology

    Nonlinear feedback drives homeostatic plasticity in H2O2 stress response

    Youlian Goulev, Sandrine Morlot ... Gilles Charvin
    Nonlinear H2O2 scavenging by peroxiredoxins drives acquired stress resistance and replicative lifespan hormesis.
    1. Cell Biology
    2. Genetics and Genomics

    Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation

    Simon Stenberg, Jing Li ... Jonas Warringer
    Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    New insights into the cellular temporal response to proteostatic stress

    Justin Rendleman, Zhe Cheng ... Christine Vogel
    A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

    Tammy J Bullwinkle, Noah M Reynolds ... Michael Ibba
    Translation quality control protects the cell from environmental stresses that could potentially lead to the toxic accumulation of non-proteinogenic amino acids in the proteome.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Free spermidine evokes superoxide radicals that manifest toxicity

    Vineet Kumar, Rajesh Kumar Mishra ... Dipak Dutta
    Spermidine-mediated superoxide generation affects iron homeostasis in Escherichia coli.
    1. Microbiology and Infectious Disease

    Redox controls RecA protein activity via reversible oxidation of its methionine residues

    Camille Henry, Laurent Loiseau ... Benjamin Ezraty
    RecA is inactivated by oxidative stress and repaired by the MsrA/B anti-ROS defense system.
    1. Cancer Biology
    2. Cell Biology

    NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

    Collin Yvès Ewald, John M Hourihan ... Nancy E Hynes
    Genetic analysis reveals NADPH oxidase generated reactive oxygen species as signals to re-establish cellular homeostasis during aging via activating a transcriptional response.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

    Kevin D Siegenthaler, Kristeen A Pareja ... Carolyn S Sevier
    Building on previous work (Wang et al., 2014), it is shown that the nucleotide exchange factor of the chaperone BiP (Sil1) unexpectedly facilitates the reduction of oxidized BiP.