1,080 results found
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Genetics and Genomics
    2. Medicine

    Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

    Pedrum Mohammadi-Shemirani et al.
    Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
    1. Microbiology and Infectious Disease

    Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo

    Darryl A Wesener et al.
    A method has been developed to characterize the expressed biochemical activities of gut microbial communities using retrievable, microscopic, fluorescent-labeled glass beads containing chemically bound surface biomolecules.
    1. Neuroscience

    Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

    Leanne M Holt et al.
    Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.
    1. Neuroscience

    Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism

    Chelsea L Faber et al.
    Synchronized feeding and metabolic patterns with environmental light–dark cycles is critical to maintain energy homeostasis and requires the activity of leptin-receptor neurons in the dorsomedial hypothalamus.
    1. Cell Biology
    2. Genetics and Genomics

    A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

    Dana M Talsness et al.
    An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

    Jumpei Ito et al.
    Iron derived from autophagy-mediated ferritin degradation in response to pressure overload induces lipid peroxidation, necrotic cardiomyocyte death, and heart failure in mice.
    1. Genetics and Genomics

    Alternative polyadenylation mediates genetic regulation of gene expression

    Briana E Mittleman et al.
    Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald et al.
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
    1. Cell Biology

    Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

    Irina L Rempel et al.
    In replicative ageing yeast cells, an age-dependent impediment in proper assembly of nuclear pore complexes is associated with altered nuclear transport.

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