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687 results found
    1. Neuroscience

    P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila

    Eric D Hoopfer et al.
    A sexually dimorphic circuit node controls a persistent, internal state that promotes fighting and mating in Drosophila, revealing parallels with mammalian systems suggestive of a conserved circuit "motif" controlling social behaviors.
    1. Biochemistry and Chemical Biology

    Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping

    Siqi Tian et al.
    A new biochemical method tests whether or not the pre-existing RNA structural correlations couple small molecule binding to gene expression in a paradigmatic riboswitch.
    1. Cell Biology
    2. Genetics and Genomics

    The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

    Heather P Harding et al.
    Genetic lesions that compromise the ribosome P-stalk implicate direct signalling from the ribosome to the translation initiation factor eIF2 kinase GCN2 in the cellular response to amino acid starvation.
    1. Neuroscience

    A neuropeptide regulates fighting behavior in Drosophila melanogaster

    Fengming Wu et al.
    Dsk-expressing neurons function downstream of a subset of P1 neurons to control fighting behavior.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

    Karthikeyani Chellappa et al.
    Proper gut health depends on the balance between two naturally occurring variants of a transcription factor in the colon.
    1. Neuroscience

    Excitation and inhibition onto central courtship neurons biases Drosophila mate choice

    Benjamin R Kallman et al.
    Pheromones activate excitatory and inhibitory pathways that are integrated to guide mating decisions in Drosophila melanogaster.
    1. Genetics and Genomics
    2. Neuroscience

    Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules

    Savannah G Brovero et al.
    Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
    1. Developmental Biology
    2. Neuroscience

    Transverse sinus injections drive robust whole-brain expression of transgenes

    Ali S Hamodi et al.
    A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.
    1. Neuroscience

    Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit

    Weiwei Liu et al.
    Functional dissection of a cluster of male-specific neurons in Drosophila reveals a neuronal circuit regulating male courtship in accordance with the internal drive state.
    1. Neuroscience

    The neural basis for a persistent internal state in Drosophila females

    David Deutsch et al.
    A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.

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