1,289 results found
    1. Microbiology and Infectious Disease

    CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

    David O Ajasin et al.
    Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.
    1. Microbiology and Infectious Disease

    Plasmodium P36 determines host cell receptor usage during sporozoite invasion

    Giulia Manzoni et al.
    Host CD81 and Scavenger Receptor BI operate independently to mediate invasion of hepatocytes by different species of Plasmodium sporozoites, which use the parasite protein P36 as a key determinant of the entry route.
    1. Neuroscience

    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

    Jiandong Sun et al.
    A new mechanism linking lysosomes to mTOR regulation and synaptic plasticity involves p18 ubiquitination by Ube3a, and underlies some of the pathology observed in Angelman syndrome.
    1. Biochemistry and Chemical Biology

    daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

    Jonathan D Hibshman et al.
    daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.
    1. Neuroscience

    P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila

    Eric D Hoopfer et al.
    A sexually dimorphic circuit node controls a persistent, internal state that promotes fighting and mating in Drosophila, revealing parallels with mammalian systems suggestive of a conserved circuit "motif" controlling social behaviors.
    1. Neuroscience

    Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

    Matthieu Raveau et al.
    CA1 physiology is altered in the hippocampus of Down syndrome mice during both spatial exploration and rest, paralleled by an increase in populations of interneurons responsible for single cell and network synchronization.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

    Anil M Narasimha et al.
    The retinoblastoma tumor suppressor regulates cell cycle progression when it's in 14 mono-phosphorylated isoforms.
    1. Cell Biology
    2. Developmental Biology

    Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

    Pavan Kumar P et al.
    A novel master regulatory mechanism of cell proliferation and senscence employs the lncRNA UCA1 and a CAPERα/TBX3 corepressor.
    1. Microbiology and Infectious Disease

    Malaria: Cracking Ali Baba’s code

    Oliver Billker
    A protein called P36 holds the key to how different species of malaria parasite invade liver cells.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

    Gerta Hoxhaj et al.
    The ZNRF2 enzyme helps the mTOR protein complex to sense amino acid levels and regulate mammalian cell growth.

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