852 results found
    1. Cancer Biology
    2. Cell Biology

    Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

    Sabrina F Mansilla et al.
    A new tumor suppressor function of p21, needed at each undamaged duplication cycle, ensures the adequate execution of the DNA replication program thereby protecting the genome integrity.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

    Shi Yun Yeo et al.
    Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
    1. Cell Biology
    2. Computational and Systems Biology

    Regulation of mRNA translation during mitosis

    Marvin E Tanenbaum et al.
    Ribosomal profiling reveals that translational repression is an important mechanism for cell cycle control and can complement protein degradation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MAF1 represses CDKN1A through a Pol III-dependent mechanism

    Yu-Ling Lee et al.
    Pol II-mediated transcription and chromatin looping of CDKN1A are repressed by MAF1 through the regulation of Pol III activity.
    1. Stem Cells and Regenerative Medicine

    The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

    Jie Gao et al.
    DDB1, a component of the ubiquitin proteasome system, plays a role in both hematopoietic and embryonic stem cell self-renewal and differentiation.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel et al.
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Cell Biology

    Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

    Nicolas Talarek et al.
    Inhibition of phosphatases by kinases develops Whi5 phosphorylation and cell cycle function in low cyclin-dependent kinase activity.
    1. Cell Biology
    2. Computational and Systems Biology

    A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

    Stefania Rosano et al.
    Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie et al.
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.

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