Liliana R Teixeira, Radha Akella ... Elizabeth J Goldsmith
WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and structure.
A global reduction in tRNA differentially affects brain regions and tissues in a mouse model of Polr3-related disease leading to activation of integrated stress and innate immune responses and neurodegeneration.
Genetic, cellular, and molecular analyses reveal that the reduced abundance of total nascent transcripts that occurs after irradiation is largely due to the repression of histone and rRNA encoding genes.
PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
