27 results found
    1. Immunology and Inflammation
    2. Neuroscience

    Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

    Karina Kaczmarek-Hajek et al.
    A novel BAC transgenic mouse model reveals glial restriction of P2X7 expression in the central and peripheral nervous systems.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structural basis for subtype-specific inhibition of the P2X7 receptor

    Akira Karasawa, Toshimitsu Kawate
    Crystal structures of a mammalian P2X7 receptor and structure-based functional studies reveal a novel drug-binding site and subtype-specific conformational rearrangements required for channel opening.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection

    Molly A Matty et al.
    An in vivo drug screen of FDA-approved compounds in zebrafish identified host-directed therapies against mycobacterial infection, including the drug clemastine, which targets the P2RX7-inflammasome axis to enhance bacterial control.
    1. Immunology and Inflammation

    CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

    Cristina Alarcón-Vila et al.
    A murine model of sepsis shows that the purinergic P2X7 receptor controls the release of CD14 in extracellular vesicles playing a key role in cytokine production, bacterial clearance, and survival.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

    Akira Karasawa et al.
    Functional reconstitution of a mammalian P2X7 receptor uncovers an intrinsic and lipid-dependent dye-permeable membrane pore.
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cell Biology

    ATP activation of peritubular cells drives testicular sperm transport

    David Fleck et al.
    Purinergic signaling controls mammalian sperm transport.
    1. Immunology and Inflammation

    LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

    Jack P Green et al.
    Depletion of LRRC8A provides genetic evidence for the importance of Cl- channels in NLRP3 activation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Neuroscience

    Subretinal mononuclear phagocytes induce cone segment loss via IL-1β

    Chiara M Eandi et al.
    IL-1β release from macrophages might be responsible for the unexplained cone segment loss in retinal degenerative diseases that are associated with subretinal inflammation, such as retinitis pigmentosa or geographic atrophy.

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