A naturally acquired human monoclonal antibody recognizes proteins expressed at different stages of the Plasmodium falciparum life cycle through affinity-matured homotypic interactions with glutamate-rich repeats.

Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.

The Wnt antagonist DKK3 is a key regulator of excitatory and inhibitory synapses, and its downregulation in the hippocampus restores synaptic connectivity and memory in an Alzheimer's disease mouse model.

Biochemical and structural investigations of the pH adaptability of mouse Acidic Mammalian Chitinase offer insights for designing enhanced enzyme variants that can function in both lung and gut.

Asymmetries between the shape of the left and right human cortex are highly unique to individuals, akin to a neuroanatomical fingerprint, related to cognitive function, and primarily driven by person-specific environmental influences.

Single-nucleus sequencing, anatomy, and physiology reveal heterogeneity among olivocochlear neurons (a group of cells that provide feedback to the inner ear), identify a neuropeptide-enriched subtype, and show that neuropeptide expression changes during postnatal development and after sound exposure.

High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.

Loss of YAP1/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification, rather, Hippo pathway-mediated inhibition of YAP1/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.

Chemokine CCL28 plays a key role in shaping neutrophil responses during intestinal Salmonella infection and lung Acinetobacter infection.

Cell fate-mapping with genetically-modified mouse models and cellular markers demonstrates that sensory hair cells in the vestibular portion of the inner ear are a dynamic population in adult mice that undergo cell death and replacement under normal conditions.