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    1. Genetics and Genomics
    2. Cancer Biology

    Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

    Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Incomplete
    1. Cancer Biology

    Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells

    Huanhuan Joyce Chen, Eric E Gardner ... Harold Varmus
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    The known unknowns of the Hsp90 chaperone

    Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych
    An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease
    2. Cancer Biology

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling and phosphorylation of Akt and Erk in HPV16-infected cervical cancer

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Neuroscience

    Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

    Preethi Somasundaram, Madeline M Farley ... Trent A Watkins
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

    Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics

    Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways

    Anna Herrmannová, Jan Jelínek ... Leoš Shivaya Valášek
    eIF3, despite being a general translation initiation factor, functions in mRNA-specific regulation, having a profound impact on the synthesis and activation of the MAPK pathway components and ribosomal proteins.
    1. Cancer Biology
    2. Cell Biology

    Actin networks modulate heterogeneous NF-κB dynamics in response to TNFα

    Francesca Butera, Julia E Sero ... Chris Bakal
    A live imaging and computational approach reveals feedback loops involving F-actin dynamics that regulate the NF-κB transcription factor RELA.
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